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Temperature-dependent differences in mouse gut motility are mediated by stress.
Temperature-dependent differences in mouse gut motility are mediated by stress. Lab animal Han, A., Hudson-Paz, C., Robinson, B. G., Becker, L., Jacobson, A., Kaltschmidt, J. A., Garrison, J. L., Bhatt, A. S., Monack, D. M. 2024Abstract
Researchers have advocated elevating mouse housing temperatures from the conventional ~22?°C to the mouse thermoneutral point of 30?°C to enhance translational research. However, the impact of environmental temperature on mouse gastrointestinal physiology remains largely unexplored. Here we show that mice raised at 22?°C exhibit whole gut transit speed nearly twice as fast as those raised at 30?°C, primarily driven by a threefold increase in colon transit speed. Furthermore, gut microbiota composition differs between the two temperatures but does not dictate temperature-dependent differences in gut motility. Notably, increased stress signals from the hypothalamic-pituitary-adrenal axis at 22?°C have a pivotal role in mediating temperature-dependent differences in gut motility. Pharmacological and genetic depletion of the stress hormone corticotropin-releasing hormone slows gut motility in stressed 22?°C mice but has no comparable effect in relatively unstressed 30?°C mice. In conclusion, our findings highlight that colder mouse facility temperatures significantly increase gut motility through hormonal stress pathways.
View details for DOI 10.1038/s41684-024-01376-5
View details for PubMedID 38806681
View details for PubMedCentralID 3371737