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A core outcome set for acute necrotizing pancreatitis: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study.
A core outcome set for acute necrotizing pancreatitis: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study. The journal of trauma and acute care surgery Farrell, M. S., Alseidi, A., Byerly, S., Fockens, P., Giberson, F. A., Glaser, J., Horvath, K., Jones, D., Luckhurst, C., Mowery, N., Robinson, B. R., Rodriguez, A., Singh, V. K., Siriwardena, A. K., Vege, S. S., Trikudanathan, G., Visser, B. C., Voermans, R. P., Yeh, D. D., Gelbard, R. B. 2024; 96 (6): 965-970Abstract
The management of acute necrotizing pancreatitis (ANP) has changed dramatically over the past 20 years including the use of less invasive techniques, the timing of interventions, nutritional management, and antimicrobial management. This study sought to create a core outcome set (COS) to help shape future research by establishing a minimal set of essential outcomes that will facilitate future comparisons and pooling of data while minimizing reporting bias.A modified Delphi process was performed through involvement of ANP content experts. Each expert proposed a list of outcomes for consideration, and the panel anonymously scored the outcomes on a 9-point Likert scale. Core outcome consensus defined a priori as >70% of scores receiving 7 to 9 points and <15% of scores receiving 1 to 3 points. Feedback and aggregate data were shared between rounds with interclass correlation trends used to determine the end of the study.A total of 19 experts agreed to participate in the study with 16 (84%) participating through study completion. Forty-three outcomes were initially considered with 16 reaching consensuses after four rounds of the modified Delphi process. The final COS included outcomes related to mortality, organ failure, complications, interventions/management, and social factors.Through an iterative consensus process, content experts agreed on a COS for the management of ANP. This will help shape future research to generate data suitable for pooling and other statistical analyses that may guide clinical practice.Therapeutic/Care Management; Level V.
View details for DOI 10.1097/TA.0000000000004281
View details for PubMedID 38407209