New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa.
Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa. Nature communications Tamburini, F. B., Maghini, D., Oduaran, O. H., Brewster, R., Hulley, M. R., Sahibdeen, V., Norris, S. A., Tollman, S., Kahn, K., Wagner, R. G., Wade, A. N., Wafawanaka, F., Gomez-Olive, F. X., Twine, R., Lombard, Z., H3Africa AWI-Gen Collaborative Centre, Hazelhurst, S., Bhatt, A. S., Agongo, G., Alberts, M., Ali, S., Asiki, G., Baloyi, V., Boua, P. R., Brandenburg, J., Ceballos, F. C., Chikowore, T., Choma, S., Choudhury, A., Crowther, N., Debpuur, C., Gondwe, M., Hazelhurst, S., Kahn, K., Khayeka-Wandabwa, C., Kisiangani, I., Kyobutungi, C., Lombard, Z., Mashaba, G., Mashinya, F., Mathema, T., Micklesfield, L., Mohamed, S., Mthembu, B., Mukomana, F., Nonterah, E., Norris, S. A., Oduaran, O., Oduro, A. R., Gomez-Olive, F. X., Ramsay, M., Sankoh, O., Sengupta, D., Smyth, N., Soo, C., Soodyall, H., Sorgho, H., Swiel, Y., Tambo, E., Tindana, P., Tinto, H., Tluway, F., Tollman, S., Twine, R., Wade, A., Wagner, R., Wandera, H., Kabudula, C., Ohene-Kwofie, D., Wafawanaka, F. 2022; 13 (1): 926Abstract
Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of research between these extremes limits our understanding of how the gut microbiota relates to health and disease in the majority of the world's population. Here, we evaluate gut microbiome composition in transitioning South African populations using short- and long-read sequencing. We analyze stool from adult females living in rural Bushbuckridge (n=118) or urban Soweto (n=51) and find that these microbiomes are taxonomically intermediate between those of individuals living in high-income countries and traditional communities. We demonstrate that reference collections are incomplete for characterizing microbiomes of individuals living outside high-income countries, yielding artificially low beta diversity measurements, and generate complete genomes of undescribed taxa, including Treponema, Lentisphaerae, and Succinatimonas. Our results suggest that the gut microbiome of South Africans does not conform to a simple "western-nonwestern" axis andcontains undescribed microbial diversity.
View details for DOI 10.1038/s41467-021-27917-x
View details for PubMedID 35194028