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A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants
A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants JOURNAL OF BIOMECHANICS Frank, E. H., Jin, M., Loening, A. M., Levenston, M. E., GRODZINSKY, A. J. 2000; 33 (11): 1523-1527Abstract
We have developed an incubator housed, biaxial-tissue-loading device capable of applying axial deformations as small as 1 microm and sinusoidal rotations as small as 0.01 degrees. Axial resolution is 50 nm for applying sinewaves as low as 10 microm (or 1% based on a 1 mm thickness) or as large as 100 microm. Rotational resolution is 0.0005 degrees. The machine is small enough (30 cm high x 25 cm x 20 cm) to be placed in a standard incubator for long-term tissue culture loading studies. In metabolic studies described here, application of sinusoidal macroscopic shear deformation to articular cartilage explants resulted in a significant increase in the synthesis of proteoglycan and proteins (uptake of (35)S-sulfate and (3)H-proline) over controls held at the same static offset compression.
View details for Web of Science ID 000089948900023
View details for PubMedID 10940414