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Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy
Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy FRONTIERS IN IMMUNOLOGY Gregori, S., Passerini, L., Roncarolo, M. 2015; 6Abstract
T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses in vivo. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we are facing in the further development of Treg-based therapies.
View details for DOI 10.3389/fimmu.2015.00593
View details for Web of Science ID 000366474100001
View details for PubMedID 26635807
View details for PubMedCentralID PMC4658444