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Beneficial autoimmunity in Type 1 diabetes mellitus
Beneficial autoimmunity in Type 1 diabetes mellitus TRENDS IN IMMUNOLOGY Hauben, E., Roncarolo, M. G., Nevo, U., Schwartz, M. 2005; 26 (5): 248-253Abstract
The trigger that leads to the pathogenesis of type 1 diabetes is currently unknown. It is well established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes infiltrate the pancreatic islets in a response that does not cause damage. In the second phase, which occurs only in diabetes-prone individuals and strains, autoreactive T cells acquire aggressive potential and destroy the majority of the pancreatic islets. Rodents and humans exhibit a physiological ripple of apoptotic beta-cell death shortly after birth, which induces an adaptive autoimmune response towards islet-antigens, both in diabetes-prone non-obese diabetic (NOD) mice and in mice that do not develop diabetes. Here, we propose that the early T cell-mediated autoimmune response towards islet-antigens is physiological, purposeful and beneficial.
View details for DOI 10.1016/j.it.2005.03.004
View details for Web of Science ID 000229249900005
View details for PubMedID 15866237