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Human CD4+regulatory T cells and activation-induced tolerance
Human CD4+regulatory T cells and activation-induced tolerance MICROBES AND INFECTION Hauben, E., Roncarolo, M. G. 2005; 7 (7-8): 1023-1032Abstract
In the past years growing attention has been given to the role of regulatory T (Tr) cells in inducing and monitoring peripheral tolerance. Various subsets of Tr cells have been described based on their surface phenotype and cytokine production. However, presently there are no specific reliable markers for any of the Tr subsets and their classification is based predominantly upon their mode of suppression. In addition, the molecular mechanisms underlying the induction and mode of action of all Tr cell subsets remain to be elucidated. Here we review recent developments regarding human CD4+ Tr cells, their origin, phenotype, antigen specificity and mode of suppression.
View details for DOI 10.1016/j.micinf.2005.03.027
View details for Web of Science ID 000230979200009
View details for PubMedID 15893494