New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Multiple BM harvests in pediatric donors for thalassemic siblings: safety, efficacy and ethical issues
Multiple BM harvests in pediatric donors for thalassemic siblings: safety, efficacy and ethical issues BONE MARROW TRANSPLANTATION Biral, E., Chiesa, R., Cappelli, B., Roccia, T., Frugnoli, I., Noe, A., Soliman, C., Fiori, R., Cursi, L., Cattaneo, F., Evangelio, C., Miniero, R., Ciceri, F., Roncarolo, M. G., Marktel, S. 2008; 42 (6): 379-384Abstract
Allogeneic BMT represents the only chance of cure for beta-thalassemia. Occasionally, two affected individuals from the same family share a matched healthy sibling. Moreover, a high incidence of transplant rejection is still observed in Pesaro class III patients, requiring a second BMT procedure. In these settings, one option is to perform a second BM harvest from the same donor. Although BM harvest is a safe procedure in children, ethical issues concerning this invasive practice still arise. Here, we describe our series of seven pediatric, healthy donors, who donated BM more than once in favor of their beta-thalassemic HLA-identical siblings between June 2005 and January 2008. Three donors donated BM twice to two affected siblings and four donors donated twice for the same sibling following graft rejection of the first BMT. All donors tolerated the procedures well and no relevant side effects occurred. There was no significant difference between the two harvests concerning cell yield and time to engraftment. Our experience shows that for pediatric donors, a second BM donation is safe and feasible and good cellularity can be obtained. We suggest that a second harvest of a pediatric donor can be performed when a strong indication for BMT exists.
View details for DOI 10.1038/bmt.2008.177
View details for Web of Science ID 000260007400002
View details for PubMedID 18574444