New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Immune intervention with T regulatory cells: Past lessons and future perspectives for type 1 diabetes
Immune intervention with T regulatory cells: Past lessons and future perspectives for type 1 diabetes SEMINARS IN IMMUNOLOGY Battaglia, M., Roncarolo, M. 2011; 23 (3): 182-194Abstract
In type 1 diabetes (T1D), insulin-producing pancreatic ß-cells are attacked and destroyed by the immune system. Although man-made insulin is life-saving, it is not a cure and it cannot prevent long-term complications. In addition, most T1D patients would do almost anything to achieve release from the burden of daily glucose monitoring and insulin injection. Despite the formation of very large and promising clinical trials, a means to prevent/cure T1D in humans remains elusive. This has led to an increasing interest in the possibility of using T cells with regulatory properties (Treg cells) as a biological therapy to preserve and restore tolerance to self-antigens. In the present review we will attempt to consolidate learning from the past and to describe what we now believe could in the future become a successful Treg-cell based immune intervention in T1D.
View details for DOI 10.1016/j.smim.2011.07.007
View details for Web of Science ID 000295393300005
View details for PubMedID 21831659