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DISSECTION OF THE MECHANISMS OF IMMUNE INJURY IN RHEUMATOID-ARTHRITIS, USING TOTAL LYMPHOID IRRADIATION ARTHRITIS AND RHEUMATISM Gaston, J. S., Strober, S., SOLOVERA, J. J., GANDOUR, D., Lane, N., Schurman, D., Hoppe, R. T., CHIN, R. C., Eugui, E. M., Vaughan, J. H., Allison, A. C. 1988; 31 (1): 21-30

Abstract

Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

View details for Web of Science ID A1988M309400004

View details for PubMedID 3257873